BIOMEDICAL OPTICAL IMAGING AND BIOPHOTONICS GROUP
Professor James G. Fujimoto

Publications

2015 to Present

  1. Ho M. Adhi, C. Baumal, J. Liu , J.G. Fujimoto, J.S. Duker, and N.K. Waheed, “Agreement and reproducibility of retinal pigment epithelial detachment volumetric measurements through optical coherence tomography.” Retina 35, 467-472, March 2015.
  2. Liang, G. Traverso, H-C. Lee, O.O. Ahsen, Z. Wang, B. Potsaid, M. Giacomelli, V. Jayaraman, R. Barman, A. Cable, H. Mashimo, R. Langer, and J.G. Fujimoto, “Ultrahigh speed en face OCT capsule for endoscopic imaging,” Biomed. Opt. Exp. 6, 1146-1162, March 2015.
  3. Alasil, D. Ferrara, M. Adhi, E. Brewer, M.F. Kraus, C.R. Baumal, J. Hornegger, J.G. Fujimoto, A.J. Witkin, E. Reichel, J.S. Duker, and N.K. Waheed, “En face imaging of the choroid in polypoidal choroidal vasculopathy using swept-source optical coherence tomography,” Am. J. Ophthalmol. 169, 634-643, April 2015.
  4. Lee, W. Choi, J.J. Liu, C.D. Lu, J.S. Schuman, G. Wollstein, J.S. Duker, N.K. Waheed, and J.G. Fujimoto, “Cardiac-gated en face Doppler measurement of retinal blood flow using swept source optical coherence tomography at 100,000 axial scans per second,” Invest. Ophthalmol. Vis. Sci. 56, 2522-2530, April 2015.
  5. Liu, O. Tan, S.S. Gao, A.D. Pechauer, B. Lee, C.D. Lu, J.G. Fujimoto, and D. Huang, “Postprocessing algorithms to minimize fixed-pattern artifact and reduce trigger jitter in swept source optical coherence tomography,” Opt. Exp. 28, 9824-9834, April 2015.
  6. Jia, S.T. Bailey, T.S. Hwang, S.M. McClintic, S.S. Gao, M.E. Pennesi, C.J. Flaxel, A.K. Lauer, D.J. Wilson, J. Hornegger, J.G. Fujimoto, and D. Huang, “Quantitative optical coherence tomography angiography of vascular abnormalities in the living human eye,” Proc. Natl. Acad. Sci. 112, E2395-E2402, May 2015.
  7. Wang, H-C. Lee, D. Vermeulen, L. Chen, T. Nielsen, S.Y. Park, A. Ghaemi, E. Swanson, C. Doerr, and J. Fujimoto, “Silicon photonic integrated circuit swept-source optical coherence tomography receiver with dual polarization, dual balanced, in-phase and quadrature detection,” Biomed. Opt. Exp. 6, 2562-2574, June 2015.
  8. Adhi, D. Ferrara, R.F. Mullins, C.R. Baumal, K.J. Mohler, M.F. Kraus, J. Liu, E. Badaro, T. Alasil, J. Hornegger, J.G. Fujimoto, J.S. Duker, and N.K. Waheed, “Characterization of choroidal layers in normal aging eyes with en face swept-source optical coherence tomography,” PLoS One 10, e0133080, July 2015.
  9. D. John, C.B. Burgner, B. Potsaid, M.E. Robertson, B.K. Lee, W.J. Choi, A.E. Cable, J.G. Fujimoto, and V. Jayaraman, “Wideband electrically-pumped 1050 nm MEMS-tunable VCSEL for ophthalmic imaging,” J. Lightwave Technol. 33, 3461-3468, August 2015.
  10. J. Mohler, W. Draxinger, T. Klein, J.P. Kolb, W. Wieser, C. Haritoglou, A. Kampik, J.G. Fujimoto, A.S. Neubauer, R. Huber, and A. Wolf, “Combined 60° wide-field choroidal thickness maps and high-definition en face vasculature visualization using swept-source megahertz OCT at 1050 nm,” Invest. Ophthalmol. Vis. Sci. 56, 6284–6293, October 2015.
  11. G. Giacomelli, Y. Sheikine, H. Vardeh, J.L. Connolly, and J.G. Fujimoto, “Rapid imaging of surgical breast excisions using direct temporal sampling two photon fluorescent lifetime imaging,” Biomed. Opt. Exp. 6, 4317-4325, November 2015.
  12. F. Spaide, J.G. Fujimoto, and N.K. Waheed, “Optical coherence tomography angiography,” Retina 35, 2161-2162, November 2015.
  13. F. Spaide, J.G. Fujimoto, and N.K. Waheed, “Image artifacts in optical coherence tomography,” Retina 35, 2163-2180, November 2015.
  14. Wang, Y-S. Cho, T. Soeda, L. Xing, H. Jia, A. Aguirre, R. Vergallo, Y. Minami, H. Lee, J.G Fujimoto, B. Yu, I-K. Jang, “Effects of statin therapy on three-dimensional morphology of fibrous caps in lipid plaques: Analysis using a newly developed algorithm for OCT,” Circulation 132, A14689, November 2015.
  15. Choi, E.M. Moult, N.K. Waheed, M. Adhi, B. Lee, C.D. Lu, T.E. de Carlo, V. Jayaraman, P.J. Rosenfeld, J.S. Duker, and J.G. Fujimoto, “Ultrahigh-speed swept-source optical coherence tomography angiography in nonexudative age-related macular degeneration with geographic atrophy,” Ophthalmology 122, 2532-2544, December 2015.
  16. A. Yaseen, V.J. Srinivasan, I. Gorczynska, J.G. Fujimoto, D.A. Boas, and S. Sakadžić, “Multimodal optical imaging system for in vivo investigation of cerebral oxygen delivery and energy metabolism,” Biomed. Opt. Exp. 6, 4994-5007, December 2015.
  17. Minami, Z. Wang, A.D. Aguirre, S. Lee, S. Uemura, T. Soeda, R. Vergallo, O.C. Raffel, P. Barlis, T. Itoh, H. Lee, J. Fujimoto, and I-K. Jang, “Quantitative analysis of the side-branch orifice after bifurcation stenting using en-face processing of OCT images: A comparison between Xience V and Resolute Integrity stents,” Coronary Artery Disease 27, 19-28, January 2016.
  18. Adhi, E. Badaro, J.J Liu, M.F. Kraus, C.R. Baumal, A.J. Witkin, J. Hornegger, J.G. Fujimoto, J.S. Duker, and N.K. Waheed, “Three-dimensional enhanced imaging of the vitreoretinal interface in diabetic retinopathy using swept-source optical coherence tomography,” Am. J. Ophthalmol. 162, 140-149, February 2016.
  19. K. Waheed, E.M. Moult, J.G. Fujimoto, and P.J. Rosenfeld, “Optical coherence tomography angiography of dry age-related macular degeneration,” Dev. Ophthalmol. 56, 91-100, March 2016.
  20. A. Novais, M. Adhi, R.N. Louzada, E.D. Cole, E.M. Moult, L. Husvogt, B. Lee, S. Dang, C.V.S. Regatieri, A.J. Witkin, C.R. Baumal, J. Hornegger, V. Jayaraman, J.G. Fujimoto, J.S. Duker, and N.K. Waheed, “Choroidal neovascularization analyzed on ultrahigh-speed swept source optical coherence tomography angiography compared to spectral-domain optical coherence tomography angiography,” Am. J. Ophthalmol. 164, 80-88, April 2016.
  21. A. Salz, T.E. de Carlo, M. Adhi, E. Moult, W. Choi, C.R. Baumal, A.J. Witkin, J.S. Duker, J.G. Fujimoto, and N.K. Waheed, “Select features of diabetic retinopathy on swept-source optical coherence tomographic angiography compared with fluorescein angiography and normal eyes,” JAMA Ophthalmol. 134, 644-650, June 2016.
  22. Wang, K.A. Lucy, J.S. Schuman, I.A. Sigal, R.A. Bilonick, L. Kagemann, T. Kostanyan, C. Lu, I. Grulkowski, J.G. Fujimoto, H. Ishikawa, and G. Wollstein, “Decreased lamina cribosa beam thickness and pore diameter relative to distance from the central retinal vessel trunk,” Invest. Ophthalmol. Vis. Sci. 57, 3088-3092, June 2016.
  23. Fujimoto and E. Swanson, “The development, commercialization and impact of optical coherence tomography,” Invest. Ophthalmol. Vis. Sci. 57, OCT1-OCT13, July 2016.
  24. G. Giacomelli, L. Husvogt, H. Vardeh, B.E. Faulkner-Jones, J. Hornegger, J.L. Connolly, and J.G. Fujimoto, “Virtual hematoxylin and eosin transillumination microscopy using epi-fluorescence imaging,” PLoS ONE 11, e0159337, August 2016.
  25. Lane, E.M. Moult, E.A. Novais, R.N. Louzada, E.D. Cole, B. Lee, L. Husvogt, P.A. Keane, A.K. Denniston, A.J. Witkin, C.R. Baumal, J.G. Fujimoto, J.S. Duker, and N.K. Waheed “Visualizing the choriocapillaris under drusen: Comparing 1050-nm swept-source versus 840-nm spectral-domain optical coherence tomography angiography,” Invest. Ophthalmol. Vis. Sci. 57, OCT585-OCT590, August 2016.
  26. Lane, D. Ferrara, R.N. Louzada, J.G Fujimoto, and J.M. Seddon, “Diagnosis and follow-up of non-exudative choroidal neovascularization with multiple optical coherence tomography angiography devices: A case report,” Ophthalmic Surg. Lasers Imaging Retina 47, 778-781, August 2016.
  27. -C. Lee, O.O. Ahsen, K. Liang, Z. Wang, C. Cleveland, L. Booth, B. Potsaid, V. Jayaraman, A.E. Cable, H. Mashimo, R. Langer, G. Traverso, and J.G. Fujimoto, “Circumferential optical coherence tomography angiography imaging of the swine esophagus using a micromotor balloon catheter,” Biomed. Opt. Exp. 7, 2927-2942, August 2016.
  28. Wang, Y-S. Cho, T. Soeda, Y. Minami, L. Xing, H. Jia, A. Aguirre, R. Vergallo, H. Lee, J.G. Fujimoto, B. Yu, and I-K. Jang, “Three-dimensional morphological response of lipid-rich coronary plaques to statin therapy: A serial optical coherence tomography study,” Coron. Artery Dis. 27, 350-356, August 2016.
  29. N. Louzada, D. Ferrara, E.A. Novais, E. Moult, E. Cole, M. Lane, J. Fujimoto, J.S. Duker, C.R. Baumal, “Analysis of scleral feeder vessel in myopic choroidal neovascularization using optical coherence tomography angiography,” Ophthalmic Surg. Lasers Imaging Retina 47, 960-964, October 2016.
  30. Liang, O.O. Ahsen, H-C. Lee, Z. Wang, B.M. Potsaid, M. Figueiredo, V. Jayaraman, A.E. Cable, Q. Huang, H. Mashimo, and J.G. Fujimoto, “Volumetric mapping of Barrett’s esophagus and dysplasia with en face optical coherence tomography tethered capsule,” Am. J. Gastroenterol. 111, 1664-1666, November 2016.
  31. M. Moult, N.K. Waheed, E.A. Novais, W. Choi, B. Lee, S.B. Ploner, E. Cole, R.N. Louzada, C.D. Lu, P.J. Rosenfeld, J.S. Duker, and J.G. Fujimoto, “Swept-source OCT angiography reveals choriocapillaris alterations in eyes with nascent geographic atrophy and drusen-associated geographic atrophy,” Retina 36, S2-S11, December 2016.
  32. B. Ploner, E.M. Moult, W. Choi, N.K. Waheed, B. Lee, E.A. Novais, E.D. Cole, B. Potsaid, L. Husvogt, J. Schottenhamml, A. Maier, P.J. Rosenfeld, J.S. Duker, J. Hornegger, and J.G. Fujimoto, “Toward quantitative optical coherence tomography angiography: Visualizing blood flow speeds in ocular pathology using variable interscan time analysis, Retina 36, S118-S126, December 2016.
  33. Schottenhamml, E.M. Moult, S. Ploner, B. Lee, E.A. Novais, E. Cole, S. Dang, C.D. Lu, L. Husvogt, N.K. Waheed, J.S. Duker, J. Hornegger, and J.G. Fujimoto, “An automatic, intercapillary area-based algorithm for quantifying diabetes-related capillary dropout using optical coherence tomography angiography,” Retina 36, S93-S101, December 2016.
  34. Wang, B. Potsaid, L. Chen, C. Doerr, H-C. Lee, T. Nielson, V. Jayaraman, A.E. Cable, E. Swanson, and J.G. Fujimoto, “Cubic meter volume optical coherence tomography” Optica 3, 1496-1503, December 2016.
  35. Yoshitake, M.G. Giacomelli, L.C. Cahill, D.B. Schmolze, H. Vardeh, B.E. Faulkner-Jones, J.L. Connolly, and J.G. Fujimoto, “Direct comparison between confocal and multiphoton microscopy for rapid histopathological evaluation of unfixed human breast tissue,” J. Biomed. Opt. 21, 126021—1-12, December 2016.
  36. Choi, N.K. Waheed, E. Moult, M. Adhi, B. Lee, T. De Carlo, V. Jayaraman, C.R. Baumal, J.S. Duker, and J.G. Fujimoto, “Ultrahigh speed swept source optical coherence tomography of retinal and choriocapillaris alterations in diabetic patients with and without retinopathy,” Retina 37, 1-197, e1-e7, January 2017.
  37. M. Moult, W. Choi, D.A. Boas, B. Baumann, A.C. Clermont, E.P. Feener, and J.G. Fujimoto, “Evaluating anesthetic protocols for functional blow flow imaging in the rat eye,” J. Biomed. Opt. 22, 016005—1-6, January 2017.
  38. Demirbas, R. Uecker, J.G. Fujimoto, and A. Leitenstorfer, “Multicolor lasers using birefringent filters: experimental demonstration with Cr:Nd:GSGG and Cr:LiSAF,” Opt. Exp. 25, 2594-2607, February 2017.
  39. H. Skalet, Y. Li, C.D. Lu, Y. Jia, B. Lee, L. Husvogt, A. Maier, J.G. Fujimoto, C.R. Thomas Jr., and D. Huang, “Optical coherence tomography angiography characteristics of iris melanocytic tumors,” Ophthalmology 124, 197-204, February 2017.
  40. A. Swanson and J.G. Fujimoto, “The ecosystem that powered the translation of OCT from fundamental research to clinical and commercial impact, Biomed. Opt. Exp. 8, 1638-1664, February 2017.
  41. Lee, E.A. Novais, N.K. Waheed, M. Adhi, T.E. de Carlo, E.D. Cole, E.M. Moult, W. Choi, M. Lane, C.R. Baumal, J.S. Duker, and J.G. Fujimoto, “En face Doppler optical coherence tomography measurement of total retinal blood flow in diabetic retinopathy and diabetic macular edema,” JAMA Ophthalmol. 135, 244-251, March 2017.
  42. A. Lucy, B. Wang, J.S. Schuman, R.A. Bilonick, Y. Ling, L. Kagemann, I.A. Sigal, I. Grulkowski, J.J. Liu, J.G. Fujimoto, H. Ishikawa, and G. Wollstein, “Thick prelaminar tissue decreases lamina cribosa visibility,” Invest. Ophthalmol. Vis. Sci. 58, 1751-1757, March 2017.
  43. Dermirbas, J. Wang, G.S Petrich, S. Nabanja, J.R. Birge, L.A. Kolodziejski, F.X. Kärtner, and J.G. Fujimoto, “100-nm tunable femtosecond Cr:LiSAF laser mode locked with a broadband saturable Bragg reflector,” Appl. Opt. 56, 3812-3816, May 2017.
  44. Wan, H.-C. Lee, X. Huang, T. Xu, T. Xu, X. Zeng, Z. Zhang, Y. Sheikine, J.L. Connolly, J.G. Fujimoto, and C. Zhou, “Integrated local binary pattern texture features for classification of breast tissue imaged by optical coherence tomography,” Med. Image Anal. 38, 104-116, May 2017.
  45. -C. Lee, O.O. Ahsen, J.J. Liu, T.-H. Tsai, Q. Huang, H. Mashimo, and J.G. Fujimoto, “Assessment of the radiofrequency ablation dynamics of esophageal tissue with optical coherence tomography,” J. Biomed. Opt. 22, 076001-1—11, July 2017.
  46. Liang, O.O. Ahsen, Z. Wang, H-C. Lee, W. Liang, B.M. Potsaid, T-H. Tsai, M.G. Giacomelli, V. Jayaraman, H. Mashimo, and J.G. Fujimoto, “Endoscopic forward-viewing optical coherence tomography and angiography with MHz swept source,” Opt. Lett. 42, 3193-3196, August 2017.
  47. Wang, K.A. Lucy, J.S. Schuman, H. Ishikawa, R.A. Bilonick, I.A. Sigal, L. Kagemann, C. Lu, J.G. Fujimoto, and G. Wollstein, “Location of the central retinal vessel trunk in the laminar and prelaminar tissue of healthy and glaucomatous eyes,” Sci. Rep. 7, 9930, August 2017.
  48. -C. Lee, O.O. Ahsen, K. Liang, Z. Wang, M. Figueirido, M.G. Giacomelli, B. Potsaid, Q. Huang, H. Mashimo, and J.G. Fujimoto, “Endoscopic optical coherence tomography angiography microvascular features associated with dysplasia in Barrett’s esophagus,” Gastroint. Endosc. 86, 476-484, September 2017.
  49. D. Lu, B. Lee, J. Schottenhamml, A. Maier, E.N. Pugh, Jr., and J.G. Fujimoto, “Photoreceptor layer thickness changes during dark adaptation observed with ultrahigh-resolution optical coherence tomography,” Invest. Ophthalmol. Vis. Sci. 58, 4632-4643, September 2017.
  50. D. Cole, E.M. Moult, S. Dang, W. Choi, S.B. Ploner, B. Lee, R. Louzada, E. Novais, J. Schottenhamml, L. Husvogt, A. Maier, J.G. Fujimoto, N.K. Waheed, and J.S. Duker, “The definition, rationale, and effects of thresholding in OCT angiography,” Ophthalmol. Retina 1, 435-447, September-October 2017.
  51. B. Rebhun, E.M. Moult, E.A. Novais, C. Moreira-Neto, S.B. Ploner, R.N. Louzada, B. Lee, C.R. Baumal, J.G. Fujimoto, J.S. Duker, N.K Waheed, and D.Ferrara, “Polypoidal choroidal vasculopathy on swept-source optical coherence tomography angiography with variable interscan time analysis,” Transl. Vis. Sci. Technol. 6, 4, November 2017.
  52. O. Ahsen, H.-C. Lee, K. Liang, Z. Wang, M. Figueiredo, Q. Huang, B. Potsaid, V. Jayaraman, J.G. Fujimoto, and H. Mashimo, “Ultrahigh-speed endoscopic optical coherence tomography and angiography enables delineation of lateral margins of endoscopic mucosal resection: a case report,” Therap. Adv. Gastroenterol. 10, 931-936, December 2017.
  53. C. Cahill, M.G. Giacomelli, T. Yoshitake, H. Vardeh, B.E. Faulkner-Jones, J.L. Connolly, C-K. Sun, and J.G. Fujimoto, “Rapid virtual hematoxylin and eosin histology of breast tissue specimens using a compact fluorescence nonlinear microscope,” Lab. Invest. 98, 150-160, January 2018.
  54. Liang, Z. Wang, O.O. Ahsen, H.-C. Lee, B.M. Potsaid, V. Jayaraman, A. Cable, H. Mashimo, X. Li, and J.G. Fujimoto, “Cycloid scanning for wide field optical coherence tomography endomicroscopy and angiography in vivo,” Optica 5, 36-43, January 2018.
  55. A. Moreira-Neto, E.M. Moult, J.G. Fujimoto, N.K. Waheed, and D. Ferrarra, “Choriocapillaris loss in advanced age-related macular degeneration,” J. Ophthalmol. 2018, 6 pages, January 2018.
  56. D. Lu, N.K. Waheed, A. Witkin, C.R. Baumal, J.J. Liu, B. Potsaid, A. Joseph, V. Jayaraman, A. Cable, K. Chan, J.S. Duker, and J.G. Fujimoto, “Microscope-integrated intraoperative ultrahigh-speed swept-source optical coherence tomography for widefield retinal and anterior segment imaging,” Ophthalmic Surg. Lasers Imaging Retina 49, 94-102, February 2018.
  57. Yoshitake, M.G. Giacomelli, L.M. Quintana, H. Vardeh, L.C. Cahill, B.E. Faulkner-Jones, J.L. Connolly, D. Do, and J.G. Fujimoto, “Rapid histopathological imaging of skin and breast cancer surgical specimens using immersion microscopy with ultraviolet surface excitation,” Sci. Rep. 8, 4476, March 2018.
  58. B. Rebhun, E.M. Moult, S.B. Ploner, C. Moreira-Neto, A.Yasin Alibhai, J. Schottenhamml, B. Lee, W. Choi, F.A. Rifai, M.W. Tam, L. Husvogt, C.R. Baumal, A.J. Witkin, A. Maier, P.J. Rosenfeld, J.S. Duker, J.G. Fujimoto, and N.K. Waheed, “Analyzing relative blood flow speeds in choroidal neovascularization using variable interscan time analysis OCT angiography,” Ophthalmol. Retina 2, 306-319, April 2018.
  59. Y. Alibhai, E.M. Moult, R. Shahzad, C.B. Rebhun, C. Moreira-Neto, M. McGowan, D. Lee, B. Lee, C.R. Baumal, A.J. Witkin, E. Reichel, J.S. Duker, J.G. Fujimoto, and N.K. Waheed, “Quantifying microvascular changes using OCT angiography in diabetic eyes without clinical evidence of retinopathy,” Ophthalmol. Retina 2, 418-427, May 2018.
  60. G. Giacomelli, T. Yoshitake, L.C. Cahill, H. Vardeh, L.M. Quintana, B.E. Faulkner-Jones, J. Brooker, J.L. Connolly, and J.G. Fujimoto, “Multiscale nonlinear microscopy and widefield white light imaging enables rapid histological imaging of surgical specimen margins,” Biomed. Opt. Exp. 9, 2457-2475, May 2018.
  61. Wang, K.A. Lucy, L.S. Schuman, I.A. Sigal, R.A. Bilonick, C. Lu, J. Liu, I. Grulkowski, Z. Nadler, H. Ishikawa, L. Kagemann, J.G. Fujimoto, and G. Wollstein, “Tortuous pore path through the glaucomatous lamina cribosa,” Sci. Rep. 8, 7281, May 2018.
  62. F. Spaide, J.G. Fujimoto, N.K. Waheed, S.R. Sadda, and G. Staurenghi, “Optical coherence tomography angiography,” Prog. Retin. Eye Res. 64, 1-55, May 2018.
  63. Schirrmacher, T. Köhler, J. Endres, T. Lindenberger, L. Husvogt, J.G.Fujimoto, J. Hornegger, A. Dörfler, P. Hoelter, and A.K.Maier, “Temporal and volumetric denoising via quantile sparse image prior,” Med. Image Anal. 48, 131-146, August 2018.
  64. O. Ahsen, K. Liang, H.-C. Lee, M.G. Giacomelli, Z. Wang, B.M. Potsaid, and J.G. Fujimoto, “Assessment of Barrett’s esophagus and dysplasia with ultrahigh-speed volumetric en face and cross-sectional optical coherence tomography,” Endoscopy 50, 1-12, September 2018.